Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Gabapentin is an antiepileptic drug. Its antiemetic effect is demonstrated after laparoscopic surgery, but it is not yet known whether gabapentin is effective in preventing chemotherapy induced emesis.

The purpose of this study is to determine whether the addition of gabapentin to dexamethasone plus ondansetron increase the control of chemotherapy-induced nausea and vomiting.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Faculdade de Medicina do ABC
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• First course of chemotherapy ( cisplatin or doxorubicin at a dose of at least 50mg per square meter)

• Written informed consent must be obtained before initiating the protocol procedures

Exclusion Criteria:

• ECOG 3

• Nausea and vomiting within the past 1 day

• Gastrointestinal obstruction

• Concurrent use of opioid

• Patients with brain metastases

• History of allergic or other adverse reaction to gabapentin