Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized, double-blind controlled trial comparing treatment outcomes between chlordiazepoxide, or gabapentin to treat alcohol withdrawal syndrome in alcohol dependent veteran subjects. The objective of this trial is to compare the safety and effectiveness of these two medications. Intervention is a fixed dose taper of chlordiazepoxide, or gabapentin over 6 days. Subjects will be evaluated for 7-10 days to monitor alcohol abstinence, withdrawal severity scores, adverse events including ataxia, sedation, cognitive function and alcohol craving.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: VA Salt Lake City Health Care System
• Treatments: Chlordiazepoxide; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Alcohol dependent at risk for withdrawal symptoms

Exclusion Criteria:

• Benzodiazepine dependent