Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder (FGID)
characterized by recurrent episodes of defecation related abdominal pain associated with
abnormal bowel habit. Several studies have reported significant alterations in the gut
microbiota that may promote the development and persistence of IBS. Some Bifidobacterium
species, mainly Bifidobacterium adolescentis, have a documented immunomodulatory effect and
can modulate visceral hypersensitivity or improve the integrity of the intestinal epithelium
barrier thorough its well-known ability to produce g-aminobutyric acid
Thus, designed a randomised, double-blind, placebo-controlled, parallel-arm study evaluating
the efficacy and safety of Bifidobacterium adolescentis PRL2019 on abdominal pain symptoms in
pediatric patients with Irritative bowel sindorom