The overall objective of this pilot study is to determine whether multispectral imaging
increases the diagnostic accuracy of the current standard of high-definition white-light
endoscopy for the detection of gastric neoplasia (high grade dysplasia or cancer). As part of
an NCI-funded RO1, the investigators goal is to develop a multispectral endoscopic platform
that can be used to survey a large surface area and, potentially, serve as a "red flag" for
microendoscopic imaging of small areas. In prior ex vivo evaluations of surgical and
endoscopic specimens, the investigators have identified the optical settings and illumination
wavelengths that are complementary to white-light imaging and enhance superficial mucosal and
vascular changes associated with neoplasia. Based on this initial testing, vital-dye enhanced
fluorescence imaging (VFI) and imaging with High Resolution Microendoscope (HRME) have been
identified as modalities that may be complementary to white-light imaging. The goal of this
pilot study is to preliminarily determine the accuracy of these modalities during the
endoscopic surveillance and detection of gastric neoplasia.