Gastric pH in Critically Ill Patients

• Status: Completed
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and in healing gastric acid-dependent diseases. It is unknown, whether proton pump inhibitors are more effective in increasing gastric pH than H2-receptor antagonists in critically ill patients requiring stress ulcer prophylaxis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Vienna
• Treatments: Esomeprazole; Ranitidine; Ranitidine bismuth citrate

Criteria

Inclusion Criteria:

• critically ill patients

• indication for stress ulcer prophylaxis

• gastric pH < 4

Exclusion Criteria:

• gastrointestinal bleeding

• gastric pH > 4