Gene Electrotransfer to Muscle With Plasmid AMEP in Patients With Disseminated Cancer
Status:
Terminated
Trial end date:
2015-05-01
Target enrollment:
Participant gender:
Summary
Gene transfer by electroporation (gene electrotransfer) uses short electric pulses to
transiently permeabilise the cell membrane enabling passage of plasmid DNA into the cell
cytosol. It is an efficient non-viral method for gene delivery to various tissues. In this
phase I dose-escalating study, patients will be treated with intramuscular gene
electrotransfer of plasmid AMEP. Plasmid AMEP encodes protein AMEP which bind to α5β1 og αvβ3
integrins. Primary end point of the trial is safety and secondary end points are efficacy,
pharmacokinetics and evaluation of potential discomfort associated with the treatment
procedure using VAS (Visual Analogue Scale).