Gene Expression Profile After Gonadotropin Releasing Hormone (GnRH) Agonist Trigger of Oocyte Maturation

• Status: Terminated
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare gene expression profiles in endometrial biopsies during the window of implantation after triggers of oocyte maturation using GnRH agonist or hCG and compared with their natural cycles in order to identify genes that may be dysregulated in GnRH agonist-triggered cycles.

The investigators also intend to evaluate patients feeling of well being and physical quality of life after GnRH agonist trigger compared with hCG trigger.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: UConn Health
• Collaborator: Schering-Plough
• Treatments: Chorionic Gonadotropin; Deslorelin; Hormones; Leuprolide; Triptorelin Pamoate

Criteria

Inclusion Criteria:

• Oocyte donors

• Ages between 21 and 33

• Normal baseline serum FSH < 10mIU/mL

Exclusion Criteria:

• Hypothalamic dysfunction

• Smokers

• Baseline serum FSH ≥ 10mIU/mL