Gene Expression Profiles in Predicting Chemotherapy Response in Breast Cancer
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
We hypothesize that changes in tumor gene expression profiles vary in response to different
sequences and types of chemotherapy, and that gene expression changes will correlate with
tumor response. We are also looking to correlate drug pharmacokinetics and treatment toxicity
with genotype of drug metabolizing enzymes and tranporters.Patients with metastatic breast
cancer and who have measurable primary breast tumor will be randomized to one of two
alternating sequences of adriamycin and docetaxel. Serial tumor biopsies and plasma samples
will be obtained for gene expression and proteomic studies to identify biomarkers that will
predict for chemotherapy response.