Gene and Protein Expression Profiles After Treatment of Actinic Keratoses

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this study is to investigate the effect of 5-fluorouracil, imiquimod, and melatonin for actinic keratosis on immunological gene, and protein expressions profiles. Secondarily, the aim is to assess the effect of the treatment on the histopathology of actinic keratoses.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ismail Gögenur
• Treatments: Fluorouracil; Imiquimod; Melatonin

Criteria

Inclusion Criteria:

• Participants should have a clinical diagnosis of actinic keratosis

• Participants should be 18 years old or above

• Participants must sign an informed consent

Exclusion Criteria:

• Known allergic reaction to either 5-fluorouracil , imiquimod, or melatonin

• Immunomodulating treatment

• Predictable poor compliance (due to i.e. dementia, substance abuse, psychiatric disease, life-threatening disease or language barriers)

• Pregnant or breastfeeding

• Females not in menopause (defined as no menstruation during the last 12 months) should use a secure birth control (intrauterine devices, hormonal contraceptives including - oral pills, patches, vaginal rings and injections) during the entire period of the trial