Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
The aims of the current study are to examine gene-environment interactions associated with
norepinephrine (NE) system genes (ADRA2A, SLC6A2) in ADHD, and to evaluate whether genetic
changes in norepinephrine pathway are associated with differences in functional connectivity
of white matter fiber tracts, as measured by diffusion tensor imaging (DTI). Furthermore,
this study aims to examine neurobiological markers, such as intermediate neuroimaging
phenotypes or neuropsychological endophenotypes associated with the pathophysiology of ADHD.
Through evaluating drug responses and side effects with the associated measures of clinical,
neuropsychological and neuroimaging characteristics, investigators would like to investigate
predictors of treatment response associated with NE system genes in ADHD.