The purpose of this study is being done to determine whether magnetic resonance imaging (MRI)
using inhaled hyper-polarized 129 Xenon gas can help visualize impaired lung function to
detect changes over time in Idiopathic Pulmonary Fibrosis (IPF) patients receiving approved
IPF treatments.
Subjects will undergo an approximately hour long comprehensive MRI protocol, including
administration of multiple doses of hyper-polarized 129 Xenon. The subjects will have this
initial study prior to initiation of IPF therapies. Then the subjects will have repeat
studies at 3, 6 and 12 months following the initiation of therapy. Additional studies
including pulmonary function studies, serum for bio markers, 6 minute walk distance and a
high-resolution computed tomography (HRCT) scan (only at the 6 month visit) will be performed
to determine how 129 Xenon MRI performs relative to standard of care evaluations for IPF.
The MRI uses a magnet and radio waves to make diagnostic medical images of the body. There
have been no ill effects reported from exposure to the magnetism or radio waves used in this
test. Risks of the xenon gas are slight numbness in legs, nausea, a feeling of well-being,
and mild tingling in fingertips. You will have pulmonary function testing for the study, you
may experience breathlessness or dizziness during or immediately following these tests.