General Anesthesia Emergence Induced by Methylphenidate

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess whether methylphenidate affects time of emergence from isoflurane general anesthesia. Time to emergence was defined as the time from termination of isoflurane to extubation. After stopping isoflurane infusion, when the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nicoleta Stoicea
• Treatments: Methylphenidate

Criteria

Inclusion Criteria:

• Male or female, 18 to 65 years of age

• ASA I or II

• Capable and willing to consent

• Participants literate in English language

Exclusion Criteria:

• ADHD with current use of methylphenidate

• Hypersensitivity to methylphenidate

• ASA III, IV or V

• Patients with severe visual or auditory disorder

• Illiteracy

• Presence of a clinically diagnosed anxiety, agitation, major psychiatric condition such as bipolar disorder, uncontrolled major depression, schizophrenia

• Tics or Tourette's syndrome

• Glaucoma

• Hypertension, history of atrial arrhythmias (atrial fibrillation, atrial flutter), myocardial infarction

• Taking or have taken within the past 14 days a monoamine oxidase inhibitor or MAOI (Selegiline)

• Subjects who have participated or are currently participating in a clinical trial of an investigational drug within 30 days prior to surgery

• Any condition, which in the opinion of the investigator would make subject ineligible for participation in the study such as history of unstable cardiovascular, pulmonary, renal, hepatic, neurologic (seizures), hematologic or endocrine abnormality (hyperthyroidism, unstable Diabetes type I/II)