General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the outcomes of stroke patients treated for intravascular thrombectomy, using either a local anesthetic with sedation, or a general anesthetic. Historical data will be used for those treated with the local anesthetic, and prospective data will be used for those treated with the general anesthetic.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Collaborator: University of Calgary
• Treatments: Anesthetics; Anesthetics, General; Anesthetics, Local; Lidocaine; Sevoflurane

Criteria

Inclusion Criteria:

• Acute ischemic stroke

• Age 18 or greater

• Onset (last seen well) time to treatment less than 12 hours

• Disabling stroke defined as a baseline NIHSS > 5 at the time of treatment

• Pre-stroke independent functional status in activities of daily living. Patient must be living in their own home, apartment or seniors lodge where no nursing care is required

• Pre-enrollment non-intubated state based on acceptable GCS for the prospective Cohort

• Small core proximal occlusion as confirmed by CT angiography (carotid, M1 MCA or M1 MCA equivalent)

• Intention to initiate endovascular treatment within 60 minutes of baseline non-contrast CT

• Sevoflurane used during thrombectomy

• Appropriate consent provided

Exclusion Criteria:

• Baseline non-contrast CT reveals a moderate/large core defined as extensive early ischemic changes of ASPECTS 0-5 in the territory of symptomatic intracranial occlusion

• Hemorrhagic stroke

• Clinical history, past imaging or clinical judgment suggests that the intracranial occlusion is chronic

• Intubated state based on GCS at any time prior to induction of general anesthesia for prospective cohort