Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
Status:
Recruiting
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin
(naturally occurring hormone that is made in the brain).
In this study healthy volunteers and people with knee arthritis so severe that they may need
joint replacement are recruited for a one day study. Each study participant will have an IV
catheter placed. After placement of the IV catheter oxytocin will be given by IV infusion.
Investigators will perform some tests to evaluate how oxytocin changes perceptions on the
skin. Investigators will study a painful perception by placing a probe on the skin and
heating it to 113 -117 degrees Fahrenheit (F) for 5 minutes. Each study participant will
score any pain that is experienced on a 0 to 10 scale, and most people find that pain rises
during the 5 minutes, but remains mild, usually around only 1 or 2 on the 0 to 10 scale. The
5 minute heating temperature will be determined according to the subjects pain rating during
the screening visit.
The main goal of the study is to determine the effect of oxytocin during and after a fixed
rate intravenous infusion on reduction in pain to a sustained heat stimulus in order to
generate a model for peripheral analgesia.