Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Some patients with chronic subdural hematomas and transient neurological symptoms do not
respond to standard antiepileptic drugs. The investigators think that some of them could have
cortical depression rather than epileptic discharges. After an intensive literature review,
the investigators found out that some antiepileptic dugs (Lamotrigine, Topiramate) were found
to be efficient to treat cortical depression in other conditions (migraine, subarachnoid
hemorrhage). In contrast, some other drugs (Levetiracetam) were not proved to be efficient.
Knowing that, the investigators want to compare the efficacy of Topiramate against
Levetiracetam in two different groups, the NESIS group (based on a NESIS score of 4 or more -
increased risk of cortical depression) versus a non-NESIS group (score of 3 or less -
increased risk of epileptic discharges).