Genetic Epidemiology of Responses to Antihypertensives
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
0
Participant gender:
All
Summary
To determine whether measured variation in genes coding for components of vasoconstriction
and volume regulating systems predict interindividual differences in blood pressure response
to therapy with a thiazide diuretic, hydrochlorothiazide, or an angiotensin II receptor
blocker, candesartan, in hypertensive African-Americans (N=300 treated with each drug) and in
hypertensive European Americans (N=300 treated with each drug).