Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

• Status: Withdrawn
• Trial end date: 2019-03-19
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to develop an approach to provide personalized medicine to individuals who have hypertension (high blood pressure). The investigators plan to use people's genetic characteristics (traits) to determine what medication they should use to lower their blood pressure most effectively. The investigators will give individuals one of two medications to treat hypertension (lisinopril or atenolol). The investigators believe that depending on the individuals genetic background one medication will work better in lowering their blood pressure.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: University of Utah
• Treatments: Atenolol; Lisinopril

Criteria

Inclusion Criteria:

• Male and female hypertensive participants who were previously studied in SCOR program.

Exclusion Criteria:

• Diabetes

• Taking other medications beside thyroid or estrogen supplements.