Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)

• Status: Not yet recruiting
• Trial end date: 2029-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In early breast cancer (eBC), pathological complete response (pCR) after neoadjuvant therapy acts as surrogate marker for metastasis and overall survival. Therapy intensification by adding an adjuvant therapy line (post-neoadjuvant treatment) substantially lowers the risk of relapse in high-risk breast cancer patients with residual disease after neoadjuvant treatment (non-pCR). While this approach was exemplified in two phase III trials without biomarker-stratification (CREATE-X, KATHERINE), even higher efficiency might be achieved by individualized genomic-guided post-neoadjuvant therapies.

Within the seven-arm umbrella phase-II clinical trial COGNITION-GUIDE, we aim to deliver molecularly-tailored cancer care by implementing an additional response- and genomics-guided post-neoadjuvant therapy after finishing the guideline-compliant post-neoadjuvant treatment in high-risk breast cancer patients with residual cancer burden after neoadjuvant therapy to reduce the substantial risk of local and distant relapse.

The trial evaluates not a single drug but rather a general strategy of precision oncology in the curative setting and provides the basis for future confirmatory biomarker-driven trials.

Allocation to the therapy-arms is conducted by in depth molecular characterization of tumors within the COGNITION registry program.

The study aims to show an overall benefit of the precision medicine approach in high-risk eBC patients and to allow for secondary exploratory evaluation of each study-arm.

The primary endpoint of the study is invasive Disease-Free Survival (IDFS) after 4 years measured from surgery to local or distant relapse or death. The sample size of the entire trial is 240 eligible patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: German Cancer Research Center
• Treatments: Atezolizumab; Olaparib; Pertuzumab; Trastuzumab

Criteria

Inclusion Criteria:

1. Provision of written informed consent

2. Female and male patients with non-metastatic early (stage I-III) breast cancer aged ≥18 years

3. Conducted neoadjuvant chemotherapy and surgery as well as planned or rather conducted standard post-neoadjuvant treatment (standard according to guidelines)

4. For patients with initially triple negative (TNBC) or HER2-positive breast cancer:

• Non-pCR defined as other than ypT0/is ypN0

5. For patients with initially hormone receptor positive and HER2-negative breast cancer:

Non-pCR and CPS-EG score

• ≥ 3 and ypN0, or

• ≥ 2 and ypN+

6. ECOG Performance Status ≤1

7. Acute effects of any prior therapy resolved to baseline severity or National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 (NCI CTCAE v5.0) Grade ≤1 except for adverse effects not constituting a safety risk by investigator judgement

8. Postmenopausal or evidence of non-childbearing status. For women of childbearing potential negative urine pregnancy test at post-operative screening and baseline and highly effective forms of contraception have to be in place thereafter

• Evidence of childbearing potential is defined as fertile, following menarche and until becoming post-menopausal unless permanently sterile

• Postmenopausal or evidence of non-childbearing status is defined as :

• Amenorrhea for 1 year or more without an alternative medical cause following cessation of exogenous hormonal treatments plus follicle stimulating hormone (FSH) levels in the postmenopausal range in women not using hormonal contraception or hormonal replacement therapy

• Chemotherapy-induced menopause

• Surgical sterilisation (bilateral oophorectomy, bilateral salpingectomy, total hysterectomy or tubal ligation at least 6 weeks before IMP treatment)

• Female patients with age ≥ 60 years

• A man is considered fertile after puberty unless permanently sterile by bilateral orchidectomy

9. Female patients of childbearing potential and male patients with partners of childbearing potential who are sexually active must agree to the use of two forms of contraception in combination (male condom and one highly effective method). These should be started immediately after signing the informed consent form and continued throughout the period of study treatment plus a substance-depending time period (see respective sub-protocol) for female patients and a substance-depending time period for male patients. Details on contraception and pregnancy testing for male and female patients (and if indicated their partners) under IMP treatment are described within the respective sub-protocol

10. Ability of patient to understand and comply with the protocol for the duration of the study, including treatment and scheduled visits and examinations

11. Adequate bone marrow, renal, and hepatic function defined by laboratory tests

The biomarker-guided eligibility for the respective study arm is evaluated and determined exclusively by the NCT molecular tumor board on the basis of results of the COGNITION molecular diagnostic registry platform. Biomarkers that allow inclusion in the respective arm are:

• Arm 1 (Atezolizumab, Immune Evasion ): PD-L1 positivity measure by IHC (≥1% on immune cells within the tumor), MSI-high status (measured by PCR), TMB-H (≥10mut/MB), CD274 amplification

• Arm 2 (Inavolisib, PI3K): Known/reported oncogenic mutation in PIK3Ca

• Arm 3 (Ipatasertib, AKT): Aberrations predicting increased PI3K-AKT pathway activity except PI3K-mutations, HR positive histology

• Arm 4 (Olaparib, PARP, DNA-Repair): Inactivating somatic or germline BRCA1/2 mutation

• Arm 5 (Sacituzumab Govitecan, TROP-2): Trop-2-overexpression (with IHC and except known/reported homozygous polymorphism in UGT1A1*28)

• Arm 6 (Trastuzumab / Pertuzumab, ERBBB): HER2 exon-20 insertion, Activating HER2-mutation

Exclusion Criteria:

1. Other malignancy within the last 5 years except: adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS), Stage 1 grade 1 endometrial carcinoma, or other solid tumours including lymphomas (without bone marrow involvement) curatively treated with no evidence of disease for ≥5 year

2. Concurrent severe, uncontrolled systemic disease that would place patient at undue risk or interfere with planned treatment

3. Concurrent or previous treatment within 30 days in another interventional clinical trial with an investigational anticancer therapy

4. Persistent toxicity (≥Grade 2 according to NCI CTCAE v5.0 caused by previous cancer therapy, excluding alopecia

5. Clinical signs of active infection (>Grade 2 according NCI CTCAE v5.0)

6. History of or newly diagnosed human immunodeficiency virus (HIV) infection and immunocompromised patients

7. Active Hepatitis A virus infection

8. Active hepatitis B virus (HBV) infection, defined as having a positive hepatitis B surface antigen (HBsAg) test. Patients with a past or resolved HBV infection, defined as having a negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test at screening and baseline, are eligible for the study if active HBV infection is ruled out on the basis of HBV DNA viral load per local guidelines

9. Active hepatitis C virus (HCV) infection, defined as having a positive HCV antibody test at screening and baseline confirmed by a polymerase chain reaction (PCR) positive for HCV RNA

10. Dementia or significant impairment of cognitive state

11. Epilepsy requiring pharmacologic treatment

12. Pregnancy and breast feeding

13. Inability to take oral medication and gastrointestinal disorders likely to interfere with absorption of study medication

14. Major surgery (any invasive operative procedure in which a more extensive resection is performed, e.g. a body cavity is entered, organs are removed, or normal anatomy is altered) within four weeks before screening and baseline excluding breast-tumor resection after neoadjuvant chemotherapy. Patients must have recovered from any effects of any major surgery

15. Systemic chemotherapy or radiotherapy within four weeks or a longer period depending on the characteristics of the agents used

16. Heart failure classified as New York Heart Association (NYHA) II/III/IV

17. Severe obstructive or restrictive ventilation disorder

18. Patients with clinically active tuberculosis

19. Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug

20. Is taking or requiring the continued use of any of the prohibited concomitant medications listed in the respective subprotocols at baseline

21. Patients considered a poor medical risk due to a serious, uncontrolled medical disorder or non-malignant systemic disease. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3 months) myocardial infarction, unstable spinal cord compression or, superior vena cava syndrome.