Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting
(sarcopenia) and unintentional weight loss. There are currently no approved therapies for
frailty. Ghrelin is a hormone produced by the stomach that stimulates appetite centers in the
brain. The purpose of this study is to determine the optimal subcutaneous ghrelin dose as a
potential intervention for frail elderly individuals. We will examine food intake and
metabolic parameters after placebo and ghrelin administration at three escalating
subcutaneously administered doses.