Ghrelin Effect on Beta Cell Function in Health and Disease
Status:
Unknown status
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
To determine the role of nutrient status on ghrelin regulation of insulin secretion. We
hypothesize that ghrelin and glucagon-like peptide-1 (GLP-1)(both are hormones made in the
gut,) have differential effects on β-cell function in the fed state. We will compare insulin
secretion and glucose turnover during meal ingestion using a dual glucose tracer and mixed
meal protocol in subjects receiving ghrelin or saline. We will also determine the role of
ghrelin-stimulated GLP-1 levels in this process using the GLP-1 receptor (GLP-1R) antagonist
Exendin(9-39) (Ex-9).