Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis

• Status: Completed
• Trial end date: 2016-12-14
• Target enrollment: 0
• Participant gender: All

Summary

Effect of Locally Delivered Antioxidants as An Adjunct to Non-surgical Periodontal Therapy on GCF Level of Oxidative Stress Marker; Protein Carbonyl

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Maie Sami tawfik
• Treatments: Carotenoids; Lycopene

Criteria

Inclusion Criteria:

• All subjects were free from any systemic diseases.

• Subjects for group I and II were suffering from severe chronic periodontitis (Armitage et al., 1999).

• Group III included subjects with clinically healthy periodontium.

• All subjects were between 35-60 years old.

• Both genders were included.

• Subjects were able to return for follow up visits.

• Subjects agreed to sign a written consent after the nature of the study was explained.

Exclusion Criteria:

• History of scaling and root planing or periodontal surgery < 6 months prior to initiation of the study.

• History of administration of antimicrobial drugs or over the counter antioxidants like Vit C, Vit B, β-carotene < 6 months prior to the baseline examination.

• Subjects who reported any side effects or drug allergies from antioxidants.

• Subjects with mobile teeth, abscesses and defected restorations related to the affected sites.

• Subjects with para-functional habits.

• Pregnant and lactating females.

• Smokers, alcoholic and drug abusers.

• Prisoner.

• Mentally retarded patients.