Glargine Dosing in Hospitalized Patients With Type 2 Diabetes and Renal Insufficiency
Status:
Completed
Trial end date:
2011-06-30
Target enrollment:
Participant gender:
Summary
It is imperative to devise easy to follow, yet appropriate, guidelines for insulin use in
renal-impaired patients. This will be done by comparing two regimens: 1) glargine once daily
plus mealtime glulisine based on weight alone and 2) a predetermined dosing reduction
algorithm with glargine/glulisine based on weight with reduction for decreased estimated GFR
by MDRD as follows: < 30 ml/min/1.73m2 or on dialysis reduce dose by 50% from weight based
calculation.