Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
The overall goal of this project is to understand the mechanisms by which gastric bypass
surgery improves glucose metabolism.
The central hypothesis guiding this project is that the reconfiguration of intestinal transit
with the Roux-en-Y will increase the release of insulinotropic GI hormones, termed incretins
that improve insulin secretion and glucose metabolism. The study is divided into three
specific aims.
1. To determine the role of incretin hormones on insulin secretion in patients with gastric
bypass surgery using intravenous-oral hyperglycemic clamp.
2. To compare incretin effect and glucose tolerance among patient who suffer from
hypoglycemia after RYGB and asymptomatic surgical and non-surgical individuals.
3. To quantify the contribution of GLP-1 to incretin effect enhancement following surgery.
Phase:
Early Phase 1
Details
Lead Sponsor:
Cedars-Sinai Medical Center The University of Texas Health Science Center at San Antonio