Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

• Status: Completed
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This observational study tests the hypothesis that endogenous aldosterone impairs insulin secretion and insulin sensitivity in subjects with primary aldosteronism.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University
• Collaborators: Brigham and Women's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Eplerenone; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Spironolactone

Criteria

Inclusion Criteria:

1. Ambulatory subjects, 18 to 70 years of age, inclusive

2. For female subjects, the following conditions must be met:

• postmenopausal status for at least 1 year, or

• status-post surgical sterilization, or

• if of childbearing potential, utilization of adequate birth control and willingness to undergo urine beta-hcg testing on every study day.

3. Primary aldosteronism determined by both:

• Biochemical hyperaldosteronism defined as either:

1. Plasma aldosterone ≥15 ng/dL

2. or aldosterone-to-renin ratio of ≥30 if on ACE inhibitor

3. or aldosterone-to-renin ratio of ≥40 in absence of an ACE inhibitor

• Positive suppression test defined as either:

1. failure to suppress aldosterone to <7ng/dL after intravenous 0.9% saline infusion over 2 hours

2. failure to suppress 24-hour urinary aldosterone excretion to <12 µcg with simultaneously documented urine sodium excretion >200 mmol.

Exclusion Criteria:

• Subjects presenting with any of the following will not be included in the study:

1. Previously diagnosed type 1 Diabetes

2. Type II Diabetes, as defined by ADA criteria:

• Hemoglobin A1C ≥6.5%

• Fasting plasma glucose ≥126mg/dl (7.0mmol/l)

• 2-hour 75g oral glucose tolerance test (OGTT) plasma glucose ≥200mg/dl (11.1 mmol/l) d. Current treatment with anti-diabetic medication(s)

3. Impaired renal function [estimated glomerular filtration rate (eGFR) of <30ml/min] as determined by the four-variable Modification of Diet in Renal Disease (MDRD) equation, where serum creatinine (Scr) is expressed in mg/dl and age in years.

4. Prior allergies to medications used in the study protocol (e.g. L-arginine, potassium chloride, insulin), or to drugs within the same class.

5. Screening plasma potassium >5.5 mmol/L or sodium <135 mmol/L

6. Cardiovascular disease such as recent (<6 months) myocardial infarction, presence of angina pectoris, significant arrhythmia, congestive heart failure (LV hypertrophy acceptable), deep vein thrombosis, pulmonary embolism, second or third degree heart block, mitral valve stenosis, aortic stenosis or hypertrophic cardiomyopathy

7. Breast-feeding

8. Treatment with anticoagulants

9. History of serious neurologic disease such as cerebral hemorrhage, stroke, seizure, or transient ischemic attack

10. History or presence of immunological or hematological disorders

11. Diagnosis of asthma requiring use of inhaled beta agonist >1 time per week

12. Clinically significant gastrointestinal impairment that could interfere with drug absorption

13. Impaired hepatic function [aspartate amino transaminase (AST) and/or alanine amino transaminase (ALT) >2.0 x upper limit of normal range]

14. Hematocrit <35%

15. Any underlying or acute disease requiring regular medication which could possibly pose a threat to the subject or make implementation of the protocol or interpretation of the study results difficult, such as arthritis treated with non-steroidal antiinflammatory drugs

16. Treatment with chronic systemic glucocorticoid therapy (more than 7 consecutive days in 1 month)

17. Treatment with lithium salts

18. History of alcohol or drug abuse

19. Treatment with any investigational drug in the 1 month preceding the study

20. Mental conditions rendering the subject unable to understand the nature, scope and possible consequences of the study

21. Inability to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study