Overview

Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS

Status:
Active, not recruiting
Trial end date:
2023-11-01
Target enrollment:
Participant gender:
Summary
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density. This relationship will be explored in the brain's prefrontal cortex, an area important in decision-making and impulsivity.
Phase:
Phase 1
Details
Lead Sponsor:
Yale University
Collaborator:
National Institute on Drug Abuse (NIDA)
Treatments:
Acetylcysteine
N-monoacetylcystine
Pentoxifylline
Riluzole