Overview

Glutamate Inhibitors in Glioblastoma

Status:
Not yet recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
The goal of this 1:1 randomized, multi-center, open-label phase Ib/II clinical trial is to explore the efficacy of the add-on of the anti-glutamatergic drugs gabapentin, sulfasalazine and memantine to standard chemoradiotherapy with temozolomide compared to chemoradiotherapy alone in patients with newly diagnosed glioblastoma.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Zurich
Collaborator:
Swiss National Science Foundation
Treatments:
Gabapentin
Memantine
Sulfasalazine
Temozolomide