Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and
overall hemodynamics were studied in patients undergoing elective aortic valve replacement
with severe aortic stenosis and associated left ventricular hypertrophy .
Methods: 25 patients will be included in this double-blind randomized placebo-controlled
study. Glutamate was administered intravenously immediately after aortic cross-clamp release.
The patients receive either a low dose of 30mg kg-1 h-1 (LG-group) or high dose of 60 mg kg-1
h-1 (HG-group) or placebo (P-group) at a rate of 3.3ml kg-1h-1 for 2h. Transesophageal
echocardiography (TEE) is used to measure diastolic and systolic ventricular function before
sternotomy (T0), and 2h (T2), 3h (T3) and 6h (T4) after release of cross clamp. Additionally
routine hemodynamic parameters are measured intraoperatively.