Glutamatergic Modulation of Cocaine-related Deficits
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to
cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
Despite promising preclinical findings with n-methyl-d-aspartate receptor (NMDAr) modulators,
studies with human subjects have been unsuccessful to date. The purpose of this investigation
is to examine the effects of the NMDAr antagonist ketamine, recently found to have potent
therapeutic effects in humans, on cue-induced craving and impaired motivation for quitting
cocaine in cocaine dependent participants, 24-hours post-infusion.