Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants
Status:
Completed
Trial end date:
2001-08-01
Target enrollment:
Participant gender:
Summary
This large multicenter double-masked clinical trial tested whether supplementation of
standard neonatal parenteral nutrition with glutamine would reduce the risk of death or
late-onset sepsis in extremely-low-birth-weight (ELBW, less than or equal to 1000 gm)
infants. Neonates with birth weights of 401-1000gm were randomized to standard TrophAmine or
TrophAmine supplemented with glutamine before 72 hours and continued until the infants are
tolerating full enteral feedings.