Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery
Status:
Recruiting
Trial end date:
2025-01-01
Target enrollment:
Participant gender:
Summary
The present study is a multi-center randomized prospective non-inferiority trial. The study's
primary objective is to compare the coagulation profile upon using two different TXA
administration strategies: empirical TXA administration vs. viscoelastic test-based
goal-directed TXA administration in high-risk non-cardiac surgery. The secondary objectives
include comparing the amount of bleeding, incidents of hyper-fibrinolysis, thromboembolic
complications, and postoperative seizures. Researchers assumed that goal-directed tranexamic
acid (TXA) administration using viscoelastic field tests would not be inferior to the
empirical TXA administration strategy in reducing postoperative bleeding and
hyper-fibrinolysis. It also would be beneficial in lowering TXA-induced thromboembolic
complications and seizures.
Phase:
Phase 4
Details
Lead Sponsor:
Konkuk University Medical Center
Collaborators:
Asan Medical Center Korea Health Industry Development Institute Soon Chun Hyang University