Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The present study is a multi-center randomized prospective placebo-controlled non-inferiority
trial. The study's primary objective is to compare the amounts of postoperative bleeding
using two different TXA administration strategies: empirical TXA administration vs.
viscoelastic test-based Goal-directed vs Preemptive Tranexamic Acid Administration in total
hip arthroplasty. The secondary objectives include comparing the incidents of
hyper-fibrinolysis, thromboembolic complications, and postoperative seizures. Researchers
assumed that goal-directed tranexamic acid (TXA) administration using viscoelastic field
tests would not be inferior to the empirical TXA administration strategy in reducing
postoperative bleeding and hyper-fibrinolysis. It also would be beneficial in lowering
TXA-induced thromboembolic complications and seizures.