Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid Arthritis

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the safety and efficacy of gonadotropin-releasing hormone (GnRH) antagonist therapy versus placebo in patients with moderate to severe rheumatoid arthritis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Betanien Hospital
• Collaborators: Norwegian Foundation for Health and Rehabilitation; University of Oslo
• Treatments: Cetrorelix; Hormones

Criteria

Inclusion Criteria:

• Adult between 18 years and above

• Moderate to severe disease activity

• Negative pregnancy test for women of childbearing potential

• Use of reliable method of contraception (non-hormonal) by sexually active female patients

Exclusion Criteria:

• Patients who are pregnant or breastfeeding

• Patients taking biologic therapy or prednisolone >7.5mg