Gonyautoxin in the Treatment of Chronic Tension-Type Headache

• Status: Terminated
• Trial end date: 2005-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the clinical efficacy of Gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache in accordance with International Headache Society guidelines

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chile

Criteria

Inclusion Criteria:

• Chronic tensional-type headache patients according to the International Headache Society criteria: patients with headache of a pressing or tightening quality with episodic frequency above 15 days a month

• Refractory to conventional treatments such as, orally administered analgesics, systemic muscular relaxant, corticoids and antidepressant like Amytriptiline

• Treated and controlled in the University Hospital Neurology Clinic over 2 years with duration of symptoms over 3 years

Exclusion Criteria:

• Pregnancy

• Use of headache prophylactic treatment a month prior to infiltration

• Myasthenic syndromes

• Muscular dystrophies

• Inflammatory myopathies

• Acute and chronic polineuropathies

• Use of psychotropic substances 24-hour before infiltration

• Anticoagulant treatment

• terminal illnesses (AIDS, cancer)

• drugs or alcohol abuse