Overview

Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancer

Status:
Terminated

Trial end date:
2013-05-01

Target enrollment:

Participant gender:

Summary

This phase II trial studies the impact of a presurgical endocrine therapy, consisting of goserelin with letrozole or anastrozole on the treatment of premenopausal patients with stage II-III estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Endocrine therapy reduces the amount of estrogen in the body. E+ breast cancer require estrogen, so lower levels of estrogen may slow or stop cell growth. Giving goserelin together with letrozole or anastrozole before surgery may enhance the effectiveness of, or eliminate the need for, chemotherapy

Phase:

Phase 2

Details

Lead Sponsor:

Washington University School of Medicine

Collaborator:

National Cancer Institute (NCI)

Treatments:

Anastrozole
Estrogens
Goserelin
Letrozole