Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia
Status:
Recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
This phase II trial investigates three strategies and how well they work for the reduction of
graft versus host disease in patients with acute leukemia in remission. Giving chemotherapy
and total-body irradiation before a donor peripheral blood stem cell transplant helps stop
the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and
cancer cells. It may also stop the patient's immune system from rejecting the donor's stem
cells. When the healthy stem cells from a donor are infused into the patient they may help
the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
The donated stem cells may also replace the patient's immune cells and help destroy any
remaining cancer cells.