Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy

• Status: Completed
• Trial end date: 2018-12-26
• Target enrollment: 0
• Participant gender: All

Summary

Propofol is one of the most commonly used anesthetic agents because of its ability to induce rapid and reliable collection. However, hypotension and injection pain in the induction are the most common complications. After induction of propofol; The cardiovascular system depresses, resulting in a drop in blood pressure due to decreased cardiac output and systemic vascular resistance. This may also contribute to the reduction of sympathetic tone activity in the central way, and slight reduction in the number of pulses that develop as a result of increasing vagal activity. İn order to attenuate these hemodynamic undesired effects caused by propofol, various agents were tried such as atropine, ephedrine, volume replacement ringer lactate, ketamine. Ondansetron and granisetron, which are used for postoperative nausea and vomiting prophylaxis, have been used as such. Therefore, ondansetron and granisetron were preventing hypotension induced by post-spinal and general anesthesia induction.

The investigator also tried to demonstrate the effect of granisetron, another serotonin type 3 (5-HT3) receptor antagonist for postoperative nausea and vomiting prophylaxis, on induction hypotension and intubation quality after propofol induction in this study

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital
• Treatments: Granisetron

Criteria

Inclusion Criteria:

• Laparoscopic Cholecystectomy (lap) surgery

Exclusion Criteria:

• Acute pancreatitis disease

• Cardiorespiratory disease

• Hypertension

• Anti hypertension treatments