Granisetron Versus Ondansetron: Comparative Effects on ECG, QTc
Status:
Completed
Trial end date:
2007-04-01
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting [PONV] are common and distressing symptoms after surgery
performed under general anaesthesia. 5HT3 antagonists are routinely used for prevention as
well as treatment of PONV. After IRB approval we compared the effects of ondansetron and
granisetron on the various intervals on ECG in 70 patients undergoing elective surgery for
carcinoma breast after written informed consent. The demographic data was collected. The
administration of the anaesthetic was left to the discretion of the operating room staff
specialist. In the Postoperative Recovery Room patients were randomised to receive 8 mgs of
ondansetron or 1 mg of granisetron intravenously. Serial ECGs were recorded at 0 mins (before
injection of study drug), 2 mins, 5 mins, 15mins, 1 hour and 2 hours. Pulse rate,
Non-invasive blood pressure and SpO2 were also recorded. T