Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting

• Status: Recruiting
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Intrathecal morphine (ITM) has proven to be excellent in reducing postoperative pain. However, its use has commonly been associated with the occurrence of postoperative nausea and vomiting (PONV). In recent years, the combination therapy of antiemetics comprising of a serotonin receptor antagonist and corticosteroid has been implemented to diminish the occurrence of PONV. Despite being routinely used, the evidence in the efficacy of this combination in parturients are conflicting and lacking. In this study, we wish to compare the efficacy between the combination therapy of granisetron plus dexamethasone versus granisetron alone on the occurrence of postoperative nausea and vomiting (PONV) in 126 parturients undergoing elective Caesarean delivery supplemented with intrathecal morphine.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universiti Sains Malaysia
• Treatments: Dexamethasone; Granisetron; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• American Society of Anaesthesiologists (ASA) I-II category

• 2 risks factors or more for PONV according to Apfel Score.

Exclusion Criteria:

• Unfit for spinal anaesthesia.

• Coagulopathy

• Uncorrected hypovolemia

• Indeterminate neurologic disease

• Infection at site of injection

• Raised intracranial pressure(ICP)

• Morbidly obese patients, BMI> 40 kg/m2 according to ICD-10 (International Statistical Classification of Diseases 10)

• Patients allergic towards morphine.

• Contraindicated for antiemetics use

• Granisetron: allergy towards Granisetron, prolonged QT interval

• Ondansetron: allergy towards ondansetron, prolonged QT interval

• Dexamethasone: allergy towards Dexamethasone, uncontrolled Diabetes Mellitus (DM).