Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis

• Status: Unknown status
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Granulocyte colony stimulating factor in acute liver failure and alcoholic hepatitis

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Postgraduate Institute of Medical Education and Research
• Treatments: Lenograstim; Sargramostim

Criteria

Inclusion Criteria:

• Patients with Acute Liver failure as defined by AASLD.65

• Patients with Alcoholic hepatitis defined as follows: decades of heavy alcohol use (mean intake, approximately 100 g per day).The combination of an aspartate aminotransferase level that is elevated (but <300 IU per milliliter) and a ratio of the aspartate aminotransferase level to the alanine aminotransferase level that is more than 2, a total serum bilirubin level of more than 5 mg per deciliter (86 μmol per liter), an elevated INR, and neutrophilia.

Exclusion Criteria:

• Known hypersensitivity to filgrastim

• creatinine > 150 µmol/L

• infection or hemorrhage within the last 10 days

• documented hepatocellular carcinoma

• hepatitis B,C or human immunodeficiency virus seropositivity and pregnancy