Granulocyte-Macrophage Stimulating Factor in the Treatment of Peripheral Arterial Disease
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Peripheral arterial disease is a common condition in older adults involving poor arterial
circulation in the legs leading to leg pain and debility. The body's own circulating blood
vessel stem cells may help to improve circulation. This study will test whether treatment
with the drug granulocyte macrophage colony stimulating factor (GM-CSF) will improve symptoms
and signs of peripheral arterial disease over placebo after four weeks of therapy. As well
this study will examine whether improvements in blood vessel function can be observed.
Finally, we will measure blood vessel function and stem cell levels in order to determine
whether they can help to predict whether patients wither peripheral arterial disease will
suffer further cardiovascular complications.
Phase:
Phase 2
Details
Lead Sponsor:
Emory University
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health (NIH)