Growth Hormone to Improve the Clinical Outcome of Assisted Fertility in Young Patients With Decreased Ovarian Reserve

• Status: Recruiting
• Trial end date: 2025-10-30
• Target enrollment: 0
• Participant gender: Female

Summary

This study was a prospective randomized controlled trial. Patients aged <35 years with decreased clinical reserve function (AFC<5, FSH > 10miu/ml, AMH < 1.1μg/L) and receiving IVF/ICSI assisted ovulation induction in our hospital were included in this study. After randomization using Excel(Microsoft Corporation, Albuquerque, NM, USA), these patients were divided into two groups. Group A was the experimental group, which was treated with growth hormone for 3 months (2 units per day) before IVF/ICSI. Group B was the control group, which was directly assisted by IVF/ICSI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanjing University
• Treatments: Hormones

Criteria

Inclusion Criteria:

1. Age < 35 years;

2. AFC≤5

3. FSH > 10miu/ml;

4. AMH < 1.1μg/L

(2 out of 2-4 items can be met)

Exclusion Criteria:

1. Severe male factors: spermatozoa collected by testicular sperm aspiration (TESA) or percutaneous epididymal sperm aspiration (PESA) was used for intracytoplasmic sperm injection (ICSI) cycle of single spermatozoa;

2. Patients with severe adenomyosis, endometriosis, intrauterine adhesions and other diseases that significantly affect embryo implantation;

3. Diabetes mellitus, insulin resistance;

4. chromosomal karyotype abnormality in either spouse;

5. Any pregnancy or contraindications of assisted reproductive technology;