Gut Transit Effect on Enterohepatic Circulation

• Status: Active, not recruiting
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: All

Summary

A study to determine the influence of changing intestinal transit time of the enterohepatic recirculation of bile acids.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Plymouth NHS Trust
• Treatments: Antidiarrheals; Bile Acids and Salts; Loperamide

Criteria

Inclusion Criteria:

• • Healthy volunteers between the ages of 18 and 65

Exclusion Criteria:

• Unable to consent

• Pregnant or lactating

• Known diarrhoeal disorder

• Known constipation.

• Any gastrointestinal disease or previous gastric surgery

• An episode of gastroenteritis within the last month

• Taking any acid suppressing medication

• Any significant medical condition (e.g. diabetes, renal disease)

• Any antibiotic intake within the last one-month

• Any drug with known effects on GI motility

• Known allergy or intolerance to senna or loperamide