GutHeart: Targeting Gut Microbiota to Treat Heart Failure

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this trial is to study the effect of targeting the gut microbiota in patients with heart failure (HF). First, the investigators will characterize gut microbiota composition in patients with various degree of systolic HF as compared with healthy controls. Second, the potential impact of targeting gut microbiota to improve HF will be investigated through an open label randomized controlled trial (RCT) of probiotics, antibiotics and controls. The hypothesis being tested is that the gut microbiota is altered in HF; that gut microbiota of HF patients, through interaction with the intestinal and systemic innate immune system, contribute to a low-grade systemic inflammation as well as metabolic disturbances in these patients; and that an intervention with probiotics and the non-absorbable antibiotic Rifaximin attenuates these inflammatory and metabolic disturbances and improves heart function through modulation of the gut microbiota.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oslo University Hospital
• Treatments: Rifamycins; Rifaximin

Criteria

Inclusion Criteria:

• Must be at least 18 years of age, and less than 75.

• Have heart failure in New York Heart Association class II or III

• Echocardiographically verified LVEF < 40 %.

• On optimal treatment for at least 3 months

• Must have lab values as the following:

Hemoglobin above 10 g/l; eGFR above 30 ml/min; ALT < 150 units/l

• Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to ICH GCP, and national/local regulations.

Exclusion Criteria:

• Treatment with antibiotics or probiotics within the last 12 weeks

• History of hypersensitivity to Rifaximin or other Rifamycin derived antimicrobial agents, or any of the components of Xifaxan

• History of hypersensitivity to S. boulardii, yeast, or any of the components of Precosa

• Polypharmacia with increased risk for interactions. i.e. patient with an extensive medication lists (e.g. 10 drugs or more) which may influence with the patient safety or compromise the study results

• Malignancy of any cause, excluding basal cell carcinoma of the skin

• Acute coronary syndrome over the last 12 weeks

• Severely impaired kidney function (i.e., estimated glomerular filtration rate < 30 ml/minute/1.73 m2)

• Impaired liver function (Alanine aminotransferase > 150 U/l) or decompensated liver cirrhosis classified as Child-Pugh B or C.

• On-going infection, including GI infection

• Inflammatory bowel disease

• Bowel obstruction

• Active myocarditis, including Chagas disease

• Severe primary valvular heart disease

• Atrial fibrillation with ventricular frequency > 100/min

• Any other, severe co morbid disease that must be expected to severely reduce the efficacy of the interventional products, survival or compliance

• Treatment with immunosuppressive drugs

• Treatment with rifamycins other than Rifaximin

• Central venous catheter

• Pregnancy or planned pregnancy

• Nursing

• Poor compliance

• Any reason why, in the opinion of the investigator, the patient should not participate