HCV Post-Exposure Prophylaxis for Health Care Workers

• Status: Withdrawn
• Trial end date: 2020-01-16
• Target enrollment: 0
• Participant gender: All

Summary

This is an unblinded, observational trial of sofosbuvir-velpatasvir in adult health care workers who are exposed to hepatitis C virus from needlestick injury with hollow-bore needles.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: Gilead Sciences
• Treatments: Sofosbuvir; Velpatasvir

Criteria

Inclusion Criteria:

• Healthcare worker with exposure through needlestick injury with hollow-bore needles to source patients who are HCV positive

• Healthcare worker must be HCV Ab-

Exclusion Criteria:

• HCV Ab positive

• HCV Ab negative and HCV RNA greater than 1000 IU/ml

• Active malignancy

• Positive urine pregnancy test