HDP vs NS Intra-articular Injection Among KOA With Obese Patient

• Status: Completed
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this randomized controlled trial study was to compare the effect of intra-articular injection of Hypertonic Dextrose Prolotherapy (HDP) with Normal Saline (NS) in the clinical improvement of knee osteoarthritis (KOA) patients with comorbid obesity. The main questions to be answered are:

• How does the effect of HDP versus NS intra-articular injection compare to the numerical rating score (NRS) in obese KOA patients?

• How does the effect of HDP versus NS intra-articular injection compare to scores of The Western Ontario and McMaster Universities Arthritis Index (WOMAC) in obese KOA patients?

• How does the effect of HDP versus NS intra-articular injection compare to the thickness of the femoral cartilage in obese KOA patients?

Participants who meet the inclusion and exclusion criteria will be randomized based on the order of the outpatient department each day, with odd numbers as the HDP intervention group and even numbers as NS. They received ultrasound-guided intra-articular injections on day 1 and day 30.

Researchers will compare HDP versus NS groups to see which group improves NRS, WOMAC, and femoral cartilage thickness.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rumah Sakit Umum Daerah Haji Provinsi Jawa Timur, Indonesia

Criteria

Inclusion Criteria:

• Patient was diagnosed with knee osteoarthritis (KOA).

• Patient was diagnosed with obesity.

Exclusion Criteria:

• Patient with a history of knee trauma.

• Patient with a history of knee surgery.

• Patient with a history of intra-articular injection before.