HGWD Improve the Paclitaxel-related Neurotoxicity in Patients With BC
Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
The current treatments for albumin-bound paclitaxel (nab-PTX) -related peripheral
neurotoxicity (PN) mainly included cryotherapy and compression therapy , oral B group vitamin
, and duloxetine. However, treatment effectiveness of these three methods is limited. Huangqi
Guizhi Wuwu decoction (HGWD) is an herbal formula recorded in "Synopsis of the Golden
Chamber" for improving limb pain, tingling, and numbness, which is composed of five crude
drugs (Astragali Radix, Cinnamomi Ramulus, Paeoniae Radix Alba, Zingiberis Rhizoma Recens,
and Jujubae Fructus)(9). Recently, HGWD has been shown to be effective in the treatment of
oxaliplatin- and diabetic-related PNs . But there are no prospective studies to explore the
efficacy of HGWD in the treatment of nab-PTX-induced PN in patients with BC. Therefore, we
conducted this prospective randomized controlled study to investigate the efficacy and safety
of HGWD to prevent nab-PTX-induced PN in patients with BC. The primary aim of this study was
to assess the prevention of nab-PTX-induced PN by soaking hands and/or feet with HGWD when
compared to placebo.