Overview

HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity

Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
This study will evaluate the use of reduced intensity conditioning regimen in patients with high risk hemoglobinopathy Sickle Cell and B-Thalassemia Major in combination with standard immunosuppressive medications, followed by a routine stem cell transplant in order to assess whether or not it is as effective as myeloablative high dose chemotherapy and transplant.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Northwell Health
Treatments:
Alemtuzumab
Cyclosporine
Cyclosporins
Fludarabine
Fludarabine phosphate
Melphalan
Mycophenolate mofetil
Mycophenolic Acid
Tacrolimus