No curative treatment of severe HSP nephritis is known.
Apart from corticosteroids, immunosuppressive drugs, such as azathioprine and
cyclophosphamide, have been used to treat severe HSP nephritis.Limited patient series treated
with these drugs have been described, but there are no reports of controlled trials.
Cyclosporine A have been used to treat corticosteroid-resistant or corticosteroid-dependent
nephrosis. (11) Cyclosporine A has also been used to treat HSP nephritis, but as far as we
know, there are no publications reporting such trials.
The aim of the study is to compare MP pulses and cyclosporine A for their efficacy in the
treatment of HSP nephritis.
The efficacy of the two treatments will be assessed on the basis of the duration of
nephrosis/nephritis, the maintenance of renal function and the renal biopsy findings.