HaemoDYNAMICs in Primary and Secondary Hypertension

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive haemodynamic measurement protocol utilizing radial pulse wave analysis and whole-body impedance cardiography in both supine position and during head-up tilt. For comparison, haemodynamics of subjects with chronic fatigue syndrome will also be recorded.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tampere University; University of Tampere
• Collaborators: Aarne Koskelo Foundation; Finnish Cultural Foundation; Finnish Foundation for Cardiovascular Research; Finnish Kidney Foundation; Finnish Medical Foundation; Medical Research Fund of the Tampere University Hospital, Finland; Orion Farmos Research Foundation; Paavo Nurmi Foundation; Päivikki and Sakari Sohlberg Foundation, Finland; Sigrid Jusélius Foundation; Tampere Tuberculosis Foundation; The Competitive Research Funding of Pirkanmaa Hospital District
• Treatments: Albuterol; Bisoprolol; Caseins; Glycyrrhizic Acid; Nitroglycerin

Criteria

Inclusion Criteria:

• Independent, community-dwelling adults

• Hypertensive subjects (primary or secondary hypertension)

• Normotensive control subjects

• Subjects with aortic stenosis (subgroup "aortic stenosis")

• Participants of Ironman Triathlon competition

Exclusion Criteria:

• Pregnancy

• Systolic blood pressure <90 mmHg

• Allergies to test compounds