Hair Cortisol in Asthma or Allergic Rhinitis Treated With Topical Corticosteroids

• Status: Unknown status
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to prospectively examine the relation between topical corticosteroid use and hair cortisol concentration, among patients with moderate persistent asthma or allergic rhinitis. The investigators hypothesize that patients with asthma or allergic rhinitis treated with topical corticosteroids (i.e. inhaled corticosteroids (ICS) or intranasal glucocorticoids (INGC)) have higher levels of hair cortisol after 3 months of treatment than during the 3 months prior to initiation of treatment.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meir Medical Center
• Treatments: Cortisol succinate; Glucocorticoids; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• Age of 18 years or older

• Diagnosis of asthma or allergic rhinitis, or both.

• Planned initiation of treatment with ICS and/or INGC at study recruitment, according to routine clinical practice

Exclusion Criteria:

• Use of inhaled, systemic or topical corticosteroids at study initiation, or during the previous 6 months.

• Use of topical corticosteroid ointments or cream, or systemic corticosteroids during the study period.

• Disorders associated with disruption of HPA axis (Cushing syndrome, Addison syndrome).

• Insufficient hair for analysis

• Bleaching or use of artificial hair color.

• Pregnancy